Nanovaccine-Mediated Cell Selective Delivery of Neoantigens Potentiating Adoptive Dendritic Cell Transfer for Personalized Immunization

Neoantigen vaccines and adoptive dendritic cell (DC) transfer are major clinical approaches to initiate personalized immunity in cancer patients. However, the immunization efficacy is largely limited by the in vivo trajectory including neoantigens’ access to resident DCs and DCs’ access to lymph nodes (LNs). Herein, an innovative strategy is proposed to improve personalized immunization through neoantigen-loaded nanovaccines synergized with adoptive DC transfer. It is found that it enables selective delivery of neoantigens to resident DCs and macrophages by coating cancer cell membranes onto neoantigen-loaded nanoparticles. In addition, the nanovaccines promote the secretion of chemokine C-C motif ligand 2 (CCL2), CCL3, and C-X-C motif ligand 10 from macrophages, thus potentiating the access of transferred DCs to LNs. This immunization strategy enables coordinated delivery of identified neoantigens and autologous tumor lysate-derived undefined antigens, leading to initiation of antitumor T cell immunity in a personalized manner. It significantly inhibits tumor growth in prophylactic and established mouse tumor models. The findings provide a new vision for potentiating adoptive cell transfer by nanovaccines, which may open the door to a transformative possibility for improving personalized immunization.     

一种家用手持式红外偏振光治疗仪的设计与实现

红外偏振光治疗仪是一种将红外技术与电子技术应用到医学领域的康复理疗设备,主要用于软组织损伤和慢性疼痛的康复治疗,已在医院得到了推广使用。然而,现有医院使用的台式治疗仪由于体积大、售价高等特点,不方便居家使用。为了开发体积小、售价低、家庭可用的红外偏振光治疗仪,满足家用市场的潜在需求,本文提出了一种新的便携手持式红外偏振光治疗仪,并开发了该智能控制系统。本文首先介绍了一种新的家用手持式治疗仪应具备的特点和关键技术指标,在此基础上设计了手持式治疗仪的硬件总体方案和软件架构,简要介绍了该治疗仪的一些关键技术,最终实现了治疗仪样机的研制。为了验证该样机的性能,本文通过大量的测试,结果表明,研制的手持式红外偏振光治疗仪在关键参数指标上达到了医院同类产品的水平,能够很好地满足家用的需求,具有良好的市场前景。     

汽车车身涂装沙滩银色研磨印缺陷的消除方法

经过涂装现场诸多因素的排除、面漆材料的分析及试验验证,发现了研磨印形成的主要原因。由此调整了相关的面漆材料,找到了消除汽车车身涂装沙滩银色研磨印缺陷的方法。     

Effect laws and mechanisms of different temperatures on isothermal tensile fracture morphologies of high-strength boron steel

The fracture behaviour and morphologies of high-strength boron steel were investigated at different temperatures at a constant strain rate of 0.1 s-1 based on isothermal tensile tests. Fracture mechanisms were also analyzed based on the relationship between microstructure transformation and continuous cooling transformation(CCT) curves. It is found that 1) fractures of the investigated steel at high temperatures are dimple fractures; 2) the deformation of high-strength boron steel at high temperatures accelerates diffusion transformations; thus, to obtain full martensite, a higher cooling rate is needed; and 3) the investigated steel has the best plasticity when the deformation temperature is 750 °C.     

层叠顺序对UHMWPE-铝合金板抗冲击性能影响

为探究层叠顺序对双硬度UHMWPE-铝合金板抗冲击性能影响,以高分子聚乙烯(UHMWPE)板、7075高强铝合金板为对象,利用一级轻气炮开展一系列平头和卵形弹打靶试验,对靶板弹道极限速度、能量吸收率、破坏模式等进行分析.揭示板材层叠顺序对接触式高分子聚乙烯-铝合金靶板防护性能的影响规律.结果表明:平头弹撞击下,UHMWPE板在前铝合金板在后的叠放顺序("软+硬")防护性能更高;卵形弹撞击下,两种叠放顺序靶板防护性能相近;两种叠放顺序靶板在平头弹撞击下均发生"冲塞破坏",在卵形弹冲击下均发生"延性扩孔"破坏.     

回采巷道过断层施工技术

受断层影响,巷道过断层期间掘进速度缓慢,影响采掘接替和矿井生产效率。为了更好地促进矿井生产,以23上04轨顺掘进为研究对象,采用FLAC 3D软件模拟巷道过断层时巷道围岩变形量和塑性区范围,并将围岩划分为正常围岩、过渡带和破碎带3部分。根据模拟结果可知,围岩变形量和塑性区范围都在过渡带开始增大,在破碎带达到最大值。巷道采用后退卧底法过断层,并对断层破碎带及时采用锚网索、注浆、U型钢棚进行支护,通过联合支护相互配合,可以共同提高巷道支护强度,增强巷道顶帮抗变形能力。     

液压支架可视化设计研究

分析了根据顶梁偏摆量设计液压支架四连杆的过程,简化支架模型写出了四连杆型液压支架的运动学和力学方程,提出一种基于Matlab设计液压支架四连杆和求解其运动学非线性方程组的方法,并编制成可视化计算程序。给出一设计要求实例,应用此程序设计及计算液压支架参数,用Auto CAD作图验证,计算结果准确可靠。